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Semaglutide helps regulate appetite and calorie intake, which can support sustained weight loss when used together with a reduced-calorie diet and regular physical activity
The use of GLP-1R agonists was associated with fewer intra-articular injections of steroids and a lower cartilage loss velocity from the medial femoral joint, but the direct effects of GLP-1R agonist, apart from the weight loss-mediated pathway, did not reach statistical significance
Conclusion Taking spironolactone and semaglutide together is generally considered safe for most people, provided there is clinical oversight
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